Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Guanosine 3',5'-cyclic Monophosphorothioate, β-Phenyl-1,N2-etheno-8-bromo-, Rp-Isomer, Sodium Salt
A metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM).
MilliporeSigma™ Calbiochem™ Caspase-9 Substrate I, Fluorogenic
A fluorogenic substrate for caspase-9 (ICE-LAP6, Mch6).
MilliporeSigma™ Calbiochem™ Reboxetine Mesylate
A potent and selective inhibitor of noradrenalin uptake (Ki values ar
MilliporeSigma™ Calbiochem™ Ubiquitin Isopeptidase Inhibitor I, G5
The Ubiquitin Isopeptidase Inhibitor I, G5, also referenced under CAS 108477-18-5, controls the biological activity of Ubiquitin Isopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ GCase Activator, NCGC00188758
A cell-permeable pyrazolopyrimidine-carboxamide compound that directly binds to glucocerebrosidase (GCase; Kd ∽ 9μM for NT-467 fluorescent labeled GCase) and enhances its activity and serves as a chaperone for its translocation to the lysosomal compartment in fibroblasts of patients with Gaucher disease (AC50
MilliporeSigma™ Calbiochem™ Elastase Substrate V, Fluorogenic
Elastase Substrate V, Fluorogenic, CAS 72252-90-5, is a sensitive fluorogenic substrate for the quantitative determination of human leukocyte and porcine pancreatic elastase (Km = 140 μM).
MilliporeSigma™ Calbiochem™ E-64 Protease Inhibitor
The E-64 Protease Inhibitor, also referenced under CAS 66701-25-5, controls the biological activity of E-64 Protease. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
MilliporeSigma™ Calbiochem™ GR 127935 Hydrochloride
A selective 5-HT1B/1D receptor antagon
MilliporeSigma™ Calbiochem™ TX-1918
A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eEF2-K, while it inhibits other kinases at much higher concentrations.
MilliporeSigma™ Calbiochem™ U-73343
A cell-permeable analog of U-73122 that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control.
MilliporeSigma™ Calbiochem™ ACE2 Inhibitor, MLN-4760
A cell-permeable, highly potent inhibitor of angiotensin converting enzyme 2 (ACE2; IC50 = 440 pM).
MilliporeSigma™ Calbiochem™ LDN-211904
LDN-211904 modulates the biological activity of EphB3 receptor tyrosine kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable
The Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation and Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ PFKFB3 Inhibitor, 3PO
PFKFB3 Inhibitor, 3PO, is a cell-permeable, selective inhibitor of PFK-2 (6-phosphofructo-2-Kinase) activity.
MilliporeSigma™ Calbiochem™ InSolution™ γ-Secretase Inhibitor IX
InSolution™ g-Secretase Inhibitor IX, CAS 208255-80-5, is a 25 mM (5 mg/462 μl or 10 mg/924 μl) solution of g-secretase Inhibitor IX (DAPT; Cat. No. 565770) in DMSO.